Bournemouth striker Callum Wilson has been cleared of concussion after sustaining a head injury against Leicester on Tuesday.
However, Ryan Fraser is having scans on an ankle injury and is unlikely to be involved against Southampton.
Saints midfielder Oriol Romeu will miss his first league game of the season because of suspension.
Defender Cedric Soares is fit after recovering from the illness which has ruled him out of the last two matches.
MOTD COMMENTATOR'S NOTES
Steve Wilson: "About 30 miles separate the Vitality Stadium from St Mary's - but for much of their history these two clubs have been worlds apart.