Betts, Jackie Bradley Jr. and Ortiz all went deep. The fourth five-hit game of Pedroia's career, and first since 2010, included three runs, two doubles and an RBI.
Steven Wright was perfect for 4 1/3 innings while improving his record to 12-5. The knuckleballer allowed four hits and two runs (one earned) over eight innings, walking one and equaling a career high with nine strikeouts.
Twins starter Tyler Duffey was shelled for nine hits and six runs over 2 1/3 innings. Max Kepler, who broke up the perfect game with a single to left in the fifth, had two hits on a mostly quiet night for Minnesota.