Upton went the other way against Red Sox reliever Heath Hembree with one out in the fifth for the fifth slam of his career. It is only 302 feet from home plate to the right-field foul line at Fenway Park, and Statcast™ registered Upton's 13th homer of the season with an exit velocity of 99.9 mph and a projected distance of 344 feet.
It had been a close game up to that point, with Detroit clinging to a 3-2 lead.
Tigers left-hander Daniel Norris went five innings to earn the win, scattering seven hits and two runs while walking three and striking out six.