Dustin Pedroia (3-for-3, two runs), Hanley Ramirez (2-for-4, two RBIs) and Pablo Sandoval (2-for-4, three RBIs) led the charge for the Red Sox. Jackie Bradley Jr. and Mookie Betts chipped in with two hits each.
Knuckleballer Steven Wright turned in a solid start for Boston, allowing two hits and no runs over 4 1/3 innings. Closer Craig Kimbrel fired a scoreless inning.
"I felt pretty good today," said Wright. "I felt like I was able to keep it around the strike zone. I rushed a couple of them in the fourth inning but was able to get out of it.