The Red Sox staked David Price (5-7-6-3-5, 102) to an early 3-0 lead, but he quickly gave that away.
After JC Ramirez (6-5-3-3-6, 101) walked both Andrew Benintendi and Dustin Pedroia in the first inning, Hanley Ramirez knocked a run-scoring single into right center. In the second, Mookie Betts doubled home a run before scoring on Benintendi's single.
Ben Revere singled to start the bottom of the third. He was forced at second by Yunel Escobar and then Mike Trout walked. Albert Pujols doubled in two runs and Andrelton Simmons cracked a two-run homer.
Price was hit for three straight singles in the fifth that brought in one run and Xander Bogaerts's second error of the game led to another run.