When picking against the point spread, picking against a small point spread is to virtually just pick the winner. The likelihood of one-point decisions or two-point decisions are usually minimized by larger variables. Even in a close game, a pick-six here or a turnover there can result in a larger result than the score would indicate.
In the world of gambling, the absolute worst is when you pick a low spread and the game actually goes down to the wire. That's why I was freaking out last week when Clemson took on Notre Dame. The Tigers led, 21-3, to open up the fourth quarter, giving credence to why I picked them as my lock of the week last week opposite a 1.