Smith had three TD runs. Flutie, a redshirt freshman, is the nephew of former Boston College star and 1984 Heisman Trophy winner, Doug Flutie, who threw 67 career TDs.
It's BC's most lopsided win since a 76-0 victory over Holy Cross in 1949. The Eagles' record for points and largest margin of victory was a 78-0 win over St. Anselm in 1941.
BC collected 483 total yards. Howard (0-2) was in negative-yardage until the closing minutes. It finished with 11 yards.
Boston College (2-0) led 41-0 at the end of the first quarter and 62-0 at halftime.