In the modern-day NBA, play initiation isn’t the sole responsibility of the point guard. Instead, players from all over the court are relied upon to make the right read or trigger the correct action in response to a defensive coverage.
Oftentimes, the development of a play, action, or offensive sequence isn’t down to a single player, particularly a point guard. Two-man games often play a significant part in a successful offense, especially if there are multiple two-man actions a team can go to throughout the season.
The most logical option is a big-plus-guard action, where you attack out of the pick-and-roll before finding what shot the defense is giving you.