The Michigan State Spartans ran off a 3-0 run against the Penn State Nittany Lions both straight up and against the spread, but the Lions put an emphatic end to that last year with a convincing victory in Happy Valley. Coming off a brutal loss last week, Penn State looks to rebound against the Spartans on Saturday afternoon.
College football point spread: The Nittany Lions opened as 12-point favorites, according to sportsbooks monitored by OddsShark (line updates and matchup report).
College football betting pick, via OddsShark computer: 36.8-22.2 Nittany Lions (college football picks on every game).