Iowa is 4-1 in its last five meetings with Michigan, but the Wolverines are 5-2 against the spread over the last seven encounters with the Hawkeyes. In a game with the largest spread for this series in recent memory, unbeaten Michigan takes on a struggling Iowa on Saturday night at Kinnick Stadium.
Point spread: The Wolverines opened as 18.5-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report).
College football pick, via Odds Shark computer: 49.6-13.6, Wolverines (college football picks on every game)
Why the Michigan Wolverines can cover the spread
Michigan reached 9-0 on the season and remained in the running for a spot in the College Football Playoff with a 59-3 mugging of Maryland last week, easily covering as a 29-point favorite.