Michigan owns the football rivalry with Indiana, winning the last 20 meetings in a row. But after giving the Wolverines some good games recently, the Hoosiers are 3-2 against the spread over the last five meetings. Two teams coming off tough losses meet when Indiana challenges Michigan on Saturday afternoon in Ann Arbor.
Point spread: The Wolverines opened as 28-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report).
College football pick, via Odds Shark computer: 48-21, Wolverines (College football picks on every game)
Why the Indiana Hoosiers can cover the spread
The Hoosiers had won two games in a row, but lost a tough one at home to Penn State last week, 45-31.