Ohio State struggled to cover spreads early this season but is 4-2 against the spread over its last six games. Conversely, Notre Dame started 6-1 ATS, then finished 2-3. In a matchup of two storied Midwestern football programs, the Buckeyes meet the Irish in the Fiesta Bowl on New Year's Day.
Fiesta Bowl point spread: The Buckeyes opened as six-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 39.4-30.7 Buckeyes
Why the Fighting Irish can cover the spread
Notre Dame opened 4-0 this season, even after losing starting quarterback Malik Zaire for the season to an ankle injury in Week 2.