DePaul (8-17, 1-11 Big East) had No. 2 Villanova (24-2, 11-2) on upset alert earlier this season but wasn't able to pull off the stunner on the road. Now both teams meet again, this time in the Windy City.
How to watch, listen, and stream
Game Time: Monday, February 13, 2017, at 9 p.m. ET
TV: CBS Sports Network (Andrew Catalon, Steve Lappas, Allie LaForce)
Live Stream: CBSsports.com (Where available)
Villanova is listed as a 19-point favorite, according to Oddsshark.com.
The Wildcats lead the all-time series, 23-8, over the Blue Demons.