Since becoming Big 12 conference rivals, the Oklahoma Sooners are 5-0 straight up and 3-2 against the spread in the series with the West Virginia Mountaineers. OU is a big favorite for its game against a West Virginia team that will be without its starting quarterback Saturday afternoon.
College football point spread: The Sooners opened as 21-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 49.9-31.0 Sooners (College football picks on every game)
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