Since becoming Big 12 rivals the TCU Horned Frogs are 4-1 against the Iowa State Cyclones, winning the last four meetings in a row. But ISU is 3-2 against the spread over that span, pulling off one upset, covering twice as an underdog. In a big game in the Big 12 Iowa State hosts TCU on Saturday afternoon.
College football point spread: The Horned Frogs opened as seven-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 35.8-30.4 Horned Frogs (College football picks on every game)
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