Oklahoma is a perfect 6-0 both straight up and against the spread in its last six September games, including a victory and cover over Tennessee last year. However, the Sooners will run into an improved Volunteers outfit in front of what will be a raucous crowd Saturday night in Knoxville.
Point spread: The Sooners opened as three-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 26.3-22.5 Sooners
Why the Oklahoma Sooners can cover the spread
Oklahoma opened this season with a 41-3 victory over Akron, covering the spread as 31-point chalk.