Here are our Week 6 Big 12 picks from my colleague Sam Kahn and me (all times ET). Visit our college football PickCenter page for additional information on these games and many more.
Iowa State at No. 3 Oklahoma, 12 p.m. (FOX)
Kahn: Oklahoma has won 14 straight and Iowa State is 0-17 in road games against AP top-three opponents. Expect both trends to continue as the Sooners roll. Oklahoma 42, Iowa State 14
Trotter: Oklahoma's secondary looked shaky last time out in Waco, but Iowa State couldn't do anything through the air last week against Texas.