Two NFC West teams kick off Week 6 for Thursday Night Football on Amazon.
The Seahawks, who hold a 24-7 prime-time home record since 2010, play their first of two Thursday night games this season, first hosting the San Francisco 49ers. Seattle is 10-5 on Thursday Night Football since the 2010 season, and kickoff is set for 5:15 p.m. (PT). This will be the 51st regular season meeting between the two clubs with Seattle leading the series, 29-21. Following a four-game winning streak by the Seahawks from 2020-21, the 49ers have won the last four meetings.