Left tackle Ronnie Stanley and cornerback Marlon Humphrey each signed massive extensions with the Ravens this season and neither will be available for the Week 9 game against the Indianapolis Colts.
Both players made the Pro Bowl in 2019 and will be difficult to replace in the starting lineup.
The loss of Stanley and Humphrey comes at a critical time for the Ravens, who are playing the toughest portion of their schedule against teams vying for a spot in the playoffs.
Stanley is lost for the season after suffering an ankle injury against the Steelers.