This is an interesting oddity when it comes to Orioles cards. Darold Knowles pitched only five games for the Orioles, all in 1965. He didn't fare so well, coughing up 15 runs in 14.2 innings, but he had a strong enough minor league record (56-33, 2.77 ERA) that Topps featured him on their multi-player rookie cards for three consecutive years: 1964, 1965, and 1966.
Despite his inauspicious debut, Knowles went on to have a 16-season career for eight teams, chiefly the Athletics and Senators. He was a workhouse reliever, averaging 54 games pitched from 1966 through 1979. Overall, he had a record of 66-74 with a 3.