Castillo's homer, his third of the series, came off Blue Jays reliever Danny Barnes and was his fourth since returning from the disabled list on April 23. It also erased the Jays temporary lead on Jose Bautista's three-run blast earlier in the seventh. Bautista, heating up in his own right, went deep off of Orioles reliever Mychal Givens.
The clubs traded blows for most of the night, with Manny Machado hitting a solo blast in the third inning and Mark Trumbo -- who drove in three runs -- connecting for a two-run homer off Blue Jays starter Mike Bolsinger in the fifth.