Second-half goals from James Chester and substitute Scott Hogan gave Aston Villa a 2-0 Sky Bet Championship victory at the DW Stadium that pushes Wigan closer to relegation.
The hosts were being led for the first time by interim boss Graham Barrow, but were unable to improve on their miserable home form that contributed to Warren Joyce losing his job at the start of the week.
Wigan should have been ahead inside 15 minutes, but, after reading a short back pass from Mile Jedinak, Omar Bogle could only find the side-netting from an admittedly tight angle.
Bogle and Gabriel Obertan fired wide as Wigan tried to find a way through, with Michael Jacobs at least finding the target from a 20-yard free-kick only for goalkeeper Sam Johnstone to make a routine save.