Promoted Watford could give debuts to summer signings Emmanuel Dennis, Imran Louza, Juraj Kucka and Danny Rose.
Joao Pedro and Joshua King are injured, while Nathaniel Chalobah misses out because of illness.
Villa forward Ollie Watkins is a doubt with a bruised knee, and Douglas Luiz won't be involved having played in the Copa America and Olympic Games.
New recruits Leon Bailey, Emi Buendi, Danny Ings, Ashley Young and Axel Tuanzebe are all available.
LAWRO'S PREDICTION
Aston Villa looked like an established Premier League side by the end of last season and I think that will carry on even though Jack Grealish has now left.