Trent Alexander-Arnold and Jack Grealish have been forced to withdraw from the England squad after suffering injury blows.
Liverpool's Alexander-Arnold, 24, underwent medical tests on Monday morning after the stand-in captain limped off during Sunday's match with Aston Villa at Anfield.
Alexander-Arnold felt his hamstring muscle and was substituted, with him visibly in pain as he left the pitch in the second half.
Manchester City winger Grealish, 27, missed their 5-1 win over Fulham on Saturday with a slight thigh injury and has subsequently pulled out of England duty too.