Destiny Udogie returns for Spurs after injury and suspension but Cristian Romero and Yves Bissouma are banned.
Pape Matar Sarr sustained an unspecified injury while playing for Senegal and will be assessed.
Aston Villa midfielder Jacob Ramsey has recovered from a broken metatarsal, while fit-again left-back Alex Moreno awaits his first outing of the season.
Emi Martinez, Matty Cash, John McGinn, Leon Bailey and Nicolo Zaniolo are all expected to overcome minor injuries.
Bertrand Traore is out, while Lucas Digne, Douglas Luiz and Boubacar Kamara are one booking from triggering a suspension.
MATCH FACTS
Head-to-head
- Aston Villa beat Tottenham home and away last season and can win three consecutive Premier League matches against them for only the second time, following a run of four from 1994 to 1996.