Ryan Bertrand returns for Southampton after serving a ban but fellow full-back Kyle Walker-Peters could again miss out because of a thigh injury.
Aston Villa's new £14m signing Morgan Sanson is available for the first time.
Kortney Hause remains out, while Jack Grealish and Matt Targett are one booking away from triggering an automatic suspension.
LAWRO'S PREDICTION
Aston Villa's midweek defeat against Burnley was a real thriller, and this should be another good game.
Both of these sides are attack-minded, and they both have individual match-winners too. I'm going for a Saints win, but it is very hard to call it.