Premier League clubs could secure a fifth Champions League spot if the Italian sides fail to advance further in European competitions.
The most significant international tournament has proven successful for English teams, as two clubs advanced to the quarter-final on Tuesday.
Arsenal played an insignificant 2-2 draw against PSV Eindhoven after previously humiliating the Dutch team 7-1 in front of their own stands. Mikel Arteta's side is set to take on the reigning champions Real Madrid in April.
Aston Villa, meanwhile, will take on Paris Saint-Germain in the next phase, after they confidently beat Club Brugge in the second leg to secure a 6-1 score on aggregate, marked by a brilliant display from newcomer Marco Asensio, who scored a brace, following a red card opponent Kyriani Sabbe in the 17th minute.