Reading captain Paul McShane will miss the visit of Aston Villa with a hamstring injury which kept him out of Saturday's 1-1 draw at QPR.
Defender Jake Cooper and forward Yakou Meite remain sidelined as they continue to recover from ankle injuries.
Aston Villa boss Steve Bruce is set to be without defenders Micah Richards and Tommy Elphick who have calf injuries.
Jordan Ayew and Leandro Bacuna come back into contention after being rested for Saturday's draw against Wolves.
Reading manager Jaap Stam told BBC Radio Berkshire:
"Villa's a great side to face, a big side, a side that's invested a lot of money in bringing players in to go back to the Premier League.