League One leaders Rotherham edged Port Vale 5-3 on penalties to move into the last 16 of the Papa John's Trophy.
Millers goalkeeper Viktor Johansson saved from David Amoo whose late equaliser had cancelled out Michael Smith's opener.
But League Two leaders Forest Green Rovers went out after a 4-1 shootout defeat by Chelsea Under-21s.
Lewis Hall netted the clinching spot kick after the tie had finished 1-1 after 90 minutes.
Six of the evening's 10 ties to be played were decided by the lottery of the shootout as drawn matches went straight to penalties after normal time.