Manchester United manager Ole Gunnar Solskjaer is likely to rotate his squad, with Fred and Scott McTominay among those in contention to start.
Defender Victor Lindelof missed the win over Wolves because of a back problem and could be absent again.
Aston Villa have Tyrone Mings available after serving a one-match ban.
Ross Barkley is expected to be fit for the first time since he sustained a hamstring injury early in the home defeat against Brighton on 21 November.

MATCH FACTS
Head-to-head
- Aston Villa's solitary win in the past 43 Premier League meetings came at Old Trafford in December 2009 courtesy of Gabriel Agbonlahor's headed goal (D11, L31).