Manchester City defender Nathan Ake is ruled out after being injured against Arsenal.
Kyle Walker and Ederson remain missing, while manager Pep Guardiola is unsure whether John Stones, who was an unused substitute on Sunday, is fit enough to start.
Aston Villa striker Ollie Watkins is sidelined by a hamstring issue, with Jhon Duran set to deputise for him.
Jacob Ramsey and Matty Cash are out and John McGinn completes a suspension.
MATCH FACTS
Head-to-head
- Aston Villa beat Manchester City 1-0 in December and are vying for their first league double against them since 1962-63.