Adam Lallana is the latest addition to Brighton's lengthy injury list.
James Milner, Tariq Lamptey, Pervis Estupinan, Evan Ferguson, Jack Hinshelwood, Solly March, Jan Paul van Hecke and Kauro Mitoma all remain out.
Aston Villa may have goalkeeper Emiliano Martinez available again following a hamstring issue.
Alex Moreno and Youri Tielemans will also be assessed, while Nicolo Zaniolo returned from injury as a substitute against Olympiacos on Thursday.
MATCH FACTS
Head-to-head
- Brighton have lost the past five Premier League meetings by an aggregate score of 14-3.
- Aston Villa could win six consecutive league games against a single opponent for the first time since doing so against local rivals Birmingham City between 2005-10.