Aston Villa will assess John McGinn, Douglas Luiz and Ezri Konsa, who were all substituted because of injury concerns during the win over Tottenham.
Goalkeeper Emiliano Martinez awaits his first appearance since lifting the World Cup with Argentina last month.
Wolves may give a debut to new forward Matheus Cunha, who has been included in the squad for the Villa Park clash.
Boubacar Traore, who was an unused substitute against Manchester United, could feature after a groin injury.
Head coach Julen Lopetegui also said that an unspecified player had picked up a new injury on Tuesday and would be monitored ahead of the game.