Aston Villa will hand a home debut to £12m striker Ross McCormack as they try to bounce back from a disappointing Championship and EFL Cup defeats.
Tommy Elphick, Pierluigi Gollini and Aaron Tshibola are also in line for their Villa Park bows, but James Chester's move from West Brom came too late for him to play.
Darnell Fisher and Dominic Ball are set for their first games for Rotherham.
But captain Lee Frecklington (calf) is set to be out for a couple of weeks.
Defenders Kirk Broadfoot (hamstring) and Joe Mattock (knee) should be fit.