Aston Villa could give debuts to new signings Lucas Digne and Philippe Coutinho, with the latter poised to make his first Premier League appearance in four years.
Ashley Young is still nursing a broken toe and John McGinn is banned.
Manchester United pair Luke Shaw and Scott McTominay are also suspended.
Harry Maguire, Phil Jones, Jadon Sancho and Cristiano Ronaldo all missed Monday's FA Cup win over Villa but they should be fit for this game.
LAWRO'S PREDICTION
Aston Villa were hard done by when they lost at Manchester United in the FA Cup on Monday night, and I reckon they will reverse that result at Villa Park.