Wolves' top scorer Matheus Cunha is absent because of a calf problem and Nelson Semedo is sidelined by a muscle issue.
Craig Dawson is out following groin surgery, while Rayan Ait-Nouri is doubtful and Hwang Hee-chan won't be able to play more than 45 minutes, according to head coach Gary O'Neil.
Arsenal manager Mikel Arteta has reported no new injury concerns.
This game comes too soon for long-term absentee Jurrien Timber.
MATCH FACTS
Head-to-head
- Arsenal are vying for a sixth consecutive win against Wolves.
- The Gunners have netted in each of the past 32 meetings in all competitions, the joint longest scoring streak against an opponent in the club's history (matching an ongoing run versus West Brom).