Mikel Arteta has made four changes from the side that beat Ipswich Town 1-0 last time out, with Riccardo Calafiori and Ethan Nwaneri among those to come in to the starting XI to take on Brentford in west London.
Nwaneri therefore makes his first Premier League start, while Calafiori replaces Myles Lewis-Skelly at left back. The other two players coming into the side are Thomas Partey and Mikel Merino.
Kai Havertz misses out entirely, so Gabriel Jesus continues up front. Declan Rice and Leandro Trossard are both among the subs, as is academy youngster Ismeal Kabia - who made his debut in the Carabao Cup this season.