Swansea full-back Neil Taylor is ruled out after fracturing his cheekbone in training.
Luciano Narsingh, who has joined from PSV Eindhoven, is not available for his debut because of a calf injury.
Arsenal midfielder Mesut Ozil is ready to return after missing the last three games with illness.
Mohamed Elneny is at the Africa Cup of Nations, while Theo Walcott, Santi Cazorla, Per Mertesacker and Kieran Gibbs remain injured.
Petr Cech, Laurent Koscielny and Alexis Sanchez are expected to be recalled after being rested against Preston in the FA Cup.
MOTD COMMENTATOR'S NOTES
Simon Brotherton: "Officially, this is Paul Clement's first league game in charge, with Arsenal providing the opposition - just as they did at the start of predecessor Bob Bradley's short reign.