Sutton manager Paul Doswell has admitted Arsene Wenger must field a severely weakened team if his non-league outfit are to have any chance of beating Arsenal and providing the biggest upset in FA Cup history.
Arsenal will travel to Sutton on Monday night for the concluding fixture of a fifth round which has already seen several upsets.
Lincoln, also in the National League, booked their spot in the quarter-finals with a giant-killing 1-0 victory over top-flight Burnley while League One Millwall knocked out Premier League champions Leicester.
In the last round, Theo Walcott, Danny Welbeck and Alex Oxlade-Chamberlain were among the Arsenal starters against Southampton as the Gunners cruised to a 5-0 victory.