Southampton full-back Kyle Walker-Peters has been ruled out for the foreseeable future after suffering a hamstring injury in midweek.
Romeo Lavia has returned to training but is unlikely to be considered this weekend after his lengthy absence.
Arsenal defender Oleksandr Zinchenko could come into contention after a five-match absence with a calf injury, while Bukayo Saka is expected to play.
CHRIS SUTTON'S PREDICTION
Southampton helped to finish off Arsenal's hopes of making the Champions League places last season when they beat them at St Mary's in April.
This is a very different Gunners side, though.