Southampton remain without a number of first-team players including Jannik Vestergaard and Mohammed Salisu.
Arsenal manager Mikel Arteta is unsure when Pierre-Emerick Aubameyang will be available again.
The Gunners forward missed Saturday's FA Cup defeat due to a "personal issue".
MATCH FACTS
Head-to-head
- This is the second meeting in four days following Southampton's 1-0 FA Cup win on Saturday.
- Southampton have only won one of the last 10 Premier League meetings, drawing four and losing five.
- All seven of Saints' Premier League wins against Arsenal have come at home.