There is new blood in both sides.
Crystal Palace have new midfielder Cheick Doucoure in from the start, while Gabriel Jesus and Oleksandr Zinchenko both make their debut for Arsenal.
Full team news shortly.
Arsenal know only too well from 2021-22 just how damaging a dire start to the season can be.
The Gunners began last season with three straight losses before they finally got their act in gear and started amassing the points that dragged them up the table.
Palace also had a slow start last season, losing their opening game before winning just one of eight matches of what was, admittedly, a tough initial set of fixtures.