Newcastle head coach Eddie Howe admits he's "fearing the worst" as he waits for the results of a scan on Matt Targett's hamstring injury.
The left-back's absence means Newcastle are without eight senior players.
Arsenal midfielder Emile Smith Rowe faces several weeks out because of the knee injury he sustained during last week's 5-0 win over Sheffield United.
Martin Odegaard could return to the starting XI after being restricted to one brief outing in the past two games.
MATCH FACTS
Head-to-head
- Arsenal have won 19 of their last 22 matches against Newcastle in all competitions, including a 2-0 league victory at St James' Park in May this year (D1, L2).