Fulham mounted a stunning second-half comeback to deal a massive blow to Newcastle's hopes of securing Champions League qualification.
Eddie Howe's side led at the break thanks to Jacob Murphy's strike from close range. But the Cottagers hit back through Raul Jimenez on the hour before snatching the victory late on with Rodrigo Muniz's effort.
The Magpies were hoping to dispel the memories of their last home match when they suffered a shock defeat by Bournemouth and move three three points clear of fifth-place Manchester City ahead of their clash against Arsenal on Sunday.