Manchester City are without defenders John Stones and Kyle Walker, who both suffered injuries on England duty.
Manuel Akanji, Kevin de Bruyne and Matheus Nunes have been passed fit and Ederson is likely to start after recovering from a muscle injury.
Arsenal head coach Mikel Arteta says "there's a chance" that injured trio Gabriel, Bakayo Saka and Gabriel Martinelli will recover for this game.
David Raya will return after missing the win over his parent club Brentford.
MATCH FACTS
Head-to-head
- Manchester City have won eight consecutive home matches against Arsenal in all competitions since a 2-2 Premier League draw in May 2016.