Manchester City midfielder Ilkay Gundogan is likely to be out for several months after suffering knee ligament damage against Watford.
City are still without suspended duo Fernandinho and Sergio Aguero.
Arsenal striker Danny Welbeck is expected to return to full training next week after seven months out with a knee injury.
Aaron Ramsey and Shkodran Mustafi remain injured, along with Per Mertesacker and Santi Cazorla.
MOTD COMMENTATOR'S NOTES
Steve Bower: "This is a game that could determine the festive spirit of each club after contrasting emotions in the week.
"For Manchester City, it was all about returning to winning ways; now they face a sterner examination of Pep Guardiola's methods.