Luton defenders Tom Lockyer and Teden Mengi both face fitness tests after being forced off at Brentford with respective back and knee problems.
Alfie Doughty may return from a hip injury but Albert Sambi Lokonga is ineligible against his parent club.
Arsenal will monitor Takehiro Tomiyasu, who was withdrawn as a precaution against Wolves because of a muscle issue.
Thomas Partey, Emile Smith Rowe, Fabio Vieira and Jurrien Timber remain out.
MATCH FACTS
Head-to-head
- This is the first meeting in any competition since Luton beat Arsenal 1-0 in the top flight on Boxing Day 1991 courtesy of a Mick Harford goal at Kenilworth Road.