Having last qualified for the Champions League in 2016, Arsenal travel to Spurs knowing a win will secure their return to the competition after a six-year absence.
Both sides head into the final two weeks of the season with key absentees, including the known injuries at Spurs to Sergio Reguilon, Matt Doherty, Japhet Tanganga and Oliver Skipp who will all miss the remainder of the campaign.
Thomas Partey and Kieran Tierney remain injured for the Gunners, with neither appearing likely to appear again between now and the end of the campaign.