Everton defenders Ben Godfrey and Michael Keane will miss Sean Dyche's first game in charge as they recover from respective knee injuries.
Arsenal's latest signing Jorginho could be set for a debut, while Thomas Partey will be assessed.
The Ghanaian midfielder was substituted with a rib injury during the FA Cup defeat at Manchester City.
Emile Smith Rowe is out with a thigh complaint and Mohamed Elneny, Gabriel Jesus and Reiss Nelson remain long-term absentees.
CHRIS SUTTON'S PREDICTION
Arsenal rested a few players in their FA Cup tie against Manchester City and paid the price.