Brighton midfielder Moises Caicedo is banned after accumulating five yellow cards, so Billy Gilmour may start his first league game for the club.
Danny Welbeck is doubtful to face his former side because of a muscle injury.
Alexis Mac Allister is not expected to be available following his post-World Cup break.
Arsenal will monitor the fitness of Emile Smith Rowe and Takehiro Tomiyasu, who are nearing returns from respective groin and hamstring problems.
Gabriel Jesus and Reiss Nelson remain sidelined.
CHRIS SUTTON'S PREDICTION
What a game this will be. If Arsenal go to Brighton and win then that will be a sign that they can go all the way and win the title.